Is a subcompact car, such as a Hyundai Accent or Ford Fiesta (or similar) good for long road trips?

I've been widowed for 2 years. I'm a small person and I'm looking to trade in my current midsize car, which I shared with my late husband. He was a bit large so he would never fit in a subcompact car. I do not have any children, and nobody else lives with me. I rarely carry passengers. I take long road trips a couple times a year (such as driving up to 6 hours). Will these little cars make it on the interstate highway?

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